Kusuyama Y, Nishihara T, Gen E, Saito K
Nephron. 1983;33(3):220-3. doi: 10.1159/000182946.
We studied the effect of cyclophosphamide (CPM) on development of severe glomerular lesions in a model of murine nephrotoxic nephritis (NTN). CPM treatment (300 mg/kg) before initiation of the first phase on NTN showed no host antibody depositions along the glomerular basement membrane, as revealed by immunofluorescence; however, the histological study revealed no significant difference in the degree of renal damage between the control and the CPM-treated mice. Therefore, the severe glomerular lesions in murine NTN may be induced without antibody response to nephrotoxin, in the glomerulus.
我们在小鼠肾毒性肾炎（NTN）模型中研究了环磷酰胺（CPM）对严重肾小球病变发展的影响。在NTN第一阶段开始前给予CPM治疗（300mg/kg），免疫荧光显示沿肾小球基底膜无宿主抗体沉积；然而，组织学研究显示对照组和CPM治疗组小鼠之间肾损伤程度无显著差异。因此，小鼠NTN中的严重肾小球病变可能在肾小球中无针对肾毒素的抗体反应的情况下诱发。
