小鼠狼疮性肾炎：环磷酰胺对循环及组织结合免疫反应物的影响
Murine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants.
作者信息
Cavallo T, Graves K, Granholm N A
出版信息
Clin Exp Immunol. 1984 Jan;55(1):67-73.
Abstract
We investigated the effects of cyclophosphamide (Cy) on immunoreactants of plasma and kidney of mice with lupus nephritis. Cy therapy decreased plasma concentrations of IgG, but not the concentrations of anti-DNA antibodies, C3, and C1q reactive materials; in glomeruli deposits of immunoreactants were mesangial in location and decreased overall. Although Cy arrested the nephritis of NZB/W mice, the anti-DNA activity in the renal eluates was very low and comparable in untreated and in treated mice. Immune complex systems other than, or in addition to, DNA-anti-DNA are likely to play a role in the pathogenesis and course of murine lupus nephritis.
摘要
我们研究了环磷酰胺（Cy）对狼疮性肾炎小鼠血浆和肾脏免疫反应物的影响。Cy治疗降低了血浆中IgG的浓度，但未降低抗DNA抗体、C3和C1q反应性物质的浓度；免疫反应物在肾小球中的沉积物位于系膜区，且总体减少。虽然Cy阻止了NZB/W小鼠的肾炎，但肾洗脱液中的抗DNA活性非常低，在未治疗和治疗的小鼠中相当。除DNA-抗DNA之外或与之相关的免疫复合物系统可能在小鼠狼疮性肾炎的发病机制和病程中起作用。
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