Glatt H, Protić-SabljiC M, Oesch F
Science. 1983 May 27;220(4600):961-3. doi: 10.1126/science.6342137.
Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term test for carcinogenicity and mutagenicity. Glutathione is positive in the test even at concentrations found in mammalian tissues.
大鼠肝脏和肾脏匀浆的线粒体后上清液将半胱氨酸转化为一种诱变剂，该诱变剂可使鼠伤寒沙门氏菌TA100菌株的细菌恢复对组氨酸的自主性。谷胱甘肽也可被肾脏线粒体后上清液激活，但不能被肝脏制剂激活。因此，哺乳动物的重要内源性化合物在最常用的致癌性和诱变性短期试验中呈阳性。即使在哺乳动物组织中发现的浓度下，谷胱甘肽在该试验中也呈阳性。
