Evan A P, Gattone V H, Filo R S, Leapman S B, Smith E J, Luft F C
Transplantation. 1983 May;35(5):436-41. doi: 10.1097/00007890-198305000-00009.
To elucidate abnormalities in renal morphology related to perfusion preservation, we examined kidneys perfused for 60 hr with a scanning electron microscope. In addition to tubular necrosis and fused glomerular visceral epithelial foot processes, we identified changes in the glomerular endothelial and arterial endothelial surfaces. The glomerular endothelium revealed fenestrae that were smaller and more irregular than normal, as well as abnormal bulbous projections. The arterial endothelium displayed striking degenerative changes. These abnormalities may account for the altered glomerular function and intravascular coagulation that occur in some kidneys preserved by lengthy perfusion.
为了阐明与灌注保存相关的肾脏形态异常，我们用扫描电子显微镜检查了灌注60小时的肾脏。除了肾小管坏死和融合的肾小球脏层上皮足突外，我们还发现了肾小球内皮和动脉内皮表面的变化。肾小球内皮显示窗孔比正常的更小且更不规则，还有异常的球状突起。动脉内皮呈现出明显的退行性变化。这些异常可能解释了一些通过长时间灌注保存的肾脏中出现的肾小球功能改变和血管内凝血。
