小鼠疟疾中不依赖T细胞的巨噬细胞变化。
T-independent macrophage changes in murine malaria.
作者信息
Lelchuk R, Dockrell H M, Playfair J H
出版信息
Clin Exp Immunol. 1983 Mar;51(3):487-93.
Abstract
A study to investigate the participation of T cells in macrophage-mediated responses during malaria was performed in nude (nu/nu) and littermate (nu/+) mice infected with Plasmodium berghei (PB). We found that in both groups of mice spleen cells suppressed the mitogenic response to LPS. Both nu/+ and nu/nu infected mice also showed liver macrophage activation, reflected by increased plasminogen activator release. These findings suggest that at least some of the macrophage changes during malaria infection are T-independent.
摘要
在感染伯氏疟原虫（PB）的裸鼠（nu/nu）和同窝对照小鼠（nu/+）中开展了一项研究，以调查T细胞在疟疾期间巨噬细胞介导的反应中的参与情况。我们发现，两组小鼠的脾细胞均抑制了对脂多糖的促有丝分裂反应。nu/+和nu/nu感染小鼠均表现出肝巨噬细胞活化，这通过纤溶酶原激活物释放增加得以体现。这些发现表明，疟疾感染期间巨噬细胞的至少一些变化是不依赖T细胞的。
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