Charles M A, Szekeres A, Staten M, Worcester B, Walsh K M
Diabetes Care. 1983 Mar-Apr;6 Suppl 1:29-34.
The usefulness of human insulin (Novo) in the treatment of diabetes was studied in eight insulin-dependent diabetic patients. Evaluation was carried out through three methods: (1) glucose-controlled insulin infusion system on two separate days during the patients' ingestion of mixed meals; (2) euglycemic clamp method; and (3) evaluation of patients for 3 mo using short- and intermediate-acting insulins. Employing the glucose-controlled insulin infusion system resulted in mean daily insulin requirements of 84 +/- 9 U and 85 +/- 6 U SEM for porcine and human insulin, respectively (P = NS). Plasma glucose levels attained during the euglycemic clamp were 96 +/- 3 mg/dl. At each insulin infusion rate, the steady-state glucose infusion rates for porcine insulin were 1.12 +/- 0.22, 1.90 +/- 0.58, 4.28 +/- 0.61, and 9.37 +/- 0.66 mg/kg/min compared with 1.27 +/- 0.42, 2.38 +/- 0.20, 4.25 +/- 0.43, and 8.87 +/- 0.67 mg/kg/min for human insulin. No complications of either insulin preparation were observed in the 3-mo patient evaluation. Human insulin was associated with lower levels of circulating insulin antibody (P less than 0.03). In addition, hemoglobin A1c levels decreased from 8.4 to 6.9% (P less than 0.035), and normal hemoglobin A1c levels were maintained in patients using portable insulin infusion pumps.
在8名胰岛素依赖型糖尿病患者中研究了人胰岛素（诺和灵）治疗糖尿病的有效性。通过三种方法进行评估：（1）在患者摄入混合餐期间的两个不同日子，使用葡萄糖控制胰岛素输注系统；（2）正常血糖钳夹法；（3）使用短效和中效胰岛素对患者进行3个月的评估。采用葡萄糖控制胰岛素输注系统时，猪胰岛素和人胰岛素的平均每日胰岛素需求量分别为84±9 U和85±6 U SEM（P=无显著性差异）。正常血糖钳夹期间达到的血浆葡萄糖水平为96±3 mg/dl。在每个胰岛素输注速率下，猪胰岛素的稳态葡萄糖输注速率分别为1.12±0.22、1.90±0.58、4.28±0.61和9.37±0.66 mg/kg/min，而人胰岛素分别为1.27±0.42、2.38±0.20、4.25±0.43和8.87±0.67 mg/kg/min。在3个月的患者评估中，未观察到任何一种胰岛素制剂的并发症。人胰岛素与较低水平的循环胰岛素抗体相关（P<0.03）。此外，糖化血红蛋白水平从8.4%降至6.9%（P<0.035），使用便携式胰岛素输注泵的患者维持了正常的糖化血红蛋白水平。
