Mirouze J, Benghernaout O, Pham T C, Richard J L, Bringer J, Monnier L
Nouv Presse Med. 1982 Nov 13;11(45):3331-3.
Porcine extracted monocomponent insulins and human semi-synthetic insulins obtained by enzymatic conversion of porcine insulin had exactly the same clinical effectiveness on blood glucose balance when compared with an artificial pancreas during two 48-hour studies 2 or 3 days apart. There was no significant difference between maximum and minimum blood glucose variations, glycaemic falls and Schlichtkrull coefficient. Glycaemia increased and decreased during meals at a slightly slower rate with human insulin than with porcine insulin, but the differences were not significant. With both types of insulin therapy, insulin requirements per gram of ingested carbohydrates were proportionally more important in the morning than during the rest of the day, dans baseline requirements tended to increase during the day.
在两项间隔2或3天、为期48小时的研究中，将猪提取的单组分胰岛素以及通过猪胰岛素酶促转化获得的人半合成胰岛素与人工胰腺相比，它们在血糖平衡方面具有完全相同的临床效果。最大和最小血糖变化、血糖下降和施利希特克鲁尔系数之间没有显著差异。与猪胰岛素相比，人胰岛素在进餐期间血糖升高和降低的速度略慢，但差异不显著。在两种胰岛素治疗中，每克摄入碳水化合物的胰岛素需求量在早晨比一天中的其他时间按比例更重要，并且基线需求量在白天往往会增加。
