Meuris S, Verloes A, Robyn C
Endocrinology. 1983 Jun;112(6):2221-3. doi: 10.1210/endo-112-6-2221.
Animal experiments and clinical data indicate that prolactin (PRL) induces hyperinsulinemia and even diabetes. The effects of PRL on carbohydrate metabolism may be explained by at least two different mechanisms. Either PRL induces an insulin resistance at the peripheral tissue level, or PRL has a direct cytotropic effect on the pancreatic islets. Obviously, both mechanisms inducing hyperinsulinemia may coexist. We report here immunocytochemical evidence that PRL is localized in the endocrine pancreas of the normal adult rat. More precisely, the immunoreactive PRL is distributed in the cytoplasm of insulin-secreting B cells. These findings support a direct action of PRL on the endocrine pancreas.
动物实验和临床数据表明，催乳素（PRL）可诱发高胰岛素血症甚至糖尿病。PRL对碳水化合物代谢的影响至少可由两种不同机制来解释。PRL要么在周围组织水平诱导胰岛素抵抗，要么对胰岛具有直接的亲细胞作用。显然，这两种诱发高胰岛素血症的机制可能同时存在。我们在此报告免疫细胞化学证据，表明PRL定位于正常成年大鼠的内分泌胰腺中。更确切地说，免疫反应性PRL分布在分泌胰岛素的B细胞的细胞质中。这些发现支持PRL对内分泌胰腺的直接作用。
