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[腹膜炎的药物治疗。化疗药物及抗内毒素牛磺罗宁的6年经验]

[Drug therapy of peritonitis. 6-year experience with the chemotherapeutic agent and anti-endotoxin taurolin].

作者信息

Wesch G, Petermann C, Linder M M

出版信息

Fortschr Med. 1983 Mar 31;101(12):545-50.

PMID:6343207
Abstract

Since 1976 Taurolin is applied in clinical trials in several European states. The results being submitted show a very good activity of this substance against bacteria and endotoxin. Evaluating all clinical and experimental studies in our opinion the use of antibiotics postoperatively together with Taurolin seems to be an effective treatment of peritonitis. In our hospital taurolin has become an important part of the surgical management of severe forms of peritonitis. A development of resistant bacteria is not known up to now.

摘要

自1976年以来,牛磺罗宁已在欧洲多个国家进行临床试验。提交的结果显示该物质对细菌和内毒素具有很好的活性。综合评估所有临床和实验研究后,我们认为术后联合使用抗生素和牛磺罗宁似乎是治疗腹膜炎的有效方法。在我们医院,牛磺罗宁已成为严重腹膜炎外科治疗的重要组成部分。目前尚未发现耐药菌的产生。

相似文献

1
[Drug therapy of peritonitis. 6-year experience with the chemotherapeutic agent and anti-endotoxin taurolin].[腹膜炎的药物治疗。化疗药物及抗内毒素牛磺罗宁的6年经验]
Fortschr Med. 1983 Mar 31;101(12):545-50.
2
[Antibacterial therapy of purulent peritonitis: a prospective randomized study on the effects of antibiotics and taurolin, a new chemotherapeutic and antiendotoxic agent (author's transl)].
Chir Forum Exp Klin Forsch. 1980:67-71.
3
The treatment of peritonitis by an antiseptic - taurolin.用防腐剂牛磺罗宁治疗腹膜炎
Pharmatherapeutica. 1981;2(8):517-22.
4
C controlled trial of taurolin in established bacterial peritonitis.牛磺罗宁用于确诊的细菌性腹膜炎的对照试验。
Surg Gynecol Obstet. 1978 May;146(5):721-4.
5
[Effects and side effects of taurolin in experimental peritonitis in the rat].[牛磺酸在大鼠实验性腹膜炎中的作用及副作用]
Langenbecks Arch Chir. 1986;368(3):149-62. doi: 10.1007/BF01261231.
6
Clinical studies on administration of taurolin in severe sepsis: a preliminary study.牛磺罗宁治疗严重脓毒症的临床研究:一项初步研究。
Prog Clin Biol Res. 1988;272:361-71.
7
[Taurolin gel in treatment of osteitis (author's transl)].牛磺罗宁凝胶治疗骨炎(作者译)
Aktuelle Traumatol. 1982 Jun;12(3):159-65.
8
[Intravenous and intraperitoneal administration of an antiseptic: 65 cases of diffuse peritonitis treated with taurolin].[一种防腐剂的静脉内和腹腔内给药:65例用牛磺罗宁治疗的弥漫性腹膜炎]
Helv Chir Acta. 1980 Feb;46(5-6):755-8.
9
[Treatment of postsurgical bone infections].[术后骨感染的治疗]
Fortschr Kiefer Gesichtschir. 1985;30:35-7.
10
[Treatment of chronic osteomyelitis with Taurolin-Gel (author's transl)].用牛磺罗宁凝胶治疗慢性骨髓炎(作者译)
Z Orthop Ihre Grenzgeb. 1981 Oct;119(5):540-3. doi: 10.1055/s-2008-1053331.

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Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma.探讨牛磺罗定对骨肉瘤小鼠模型肿瘤重量和微血管密度的影响。
Oncol Res. 2024 Jun 20;32(7):1163-1172. doi: 10.32604/or.2024.050907. eCollection 2024.
2
Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review).牛磺酸、其卤代胺及其 lncRNA TUG1 在炎症和癌症进展中的作用。走向治疗之路?(综述)
Int J Oncol. 2020 Sep;57(3):631-664. doi: 10.3892/ijo.2020.5100. Epub 2020 Jul 14.
3
Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review).
氧化还原导向的癌症治疗:牛磺罗定和胡椒碱作为广谱有效的抗肿瘤药物(综述)
Int J Oncol. 2014 Oct;45(4):1329-36. doi: 10.3892/ijo.2014.2566. Epub 2014 Jul 28.
4
Oral administration of the anti-proliferative substance taurolidine has no impact on dextran sulfate sodium induced colitis-associated carcinogenesis in mice.口服抗增殖物质牛磺罗定对葡聚糖硫酸钠诱导的小鼠结肠炎相关致癌作用没有影响。
J Carcinog. 2010 Apr 16;9:5. doi: 10.4103/1477-3163.62536.
5
Pharmacokinetics of taurolidine following repeated intravenous infusions measured by HPLC-ESI-MS/MS of the derivatives taurultame and taurinamide in glioblastoma patients.通过高效液相色谱-电喷雾串联质谱法(HPLC-ESI-MS/MS)测定胶质母细胞瘤患者重复静脉输注牛磺罗定后其衍生物牛磺他胺和牛磺酰胺的药代动力学。
Clin Pharmacokinet. 2007;46(6):513-24. doi: 10.2165/00003088-200746060-00005.
6
Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia.
Int J Colorectal Dis. 2007 Jul;22(7):807-17. doi: 10.1007/s00384-006-0239-x. Epub 2006 Nov 21.
7
[Effects and side effects of taurolin in experimental peritonitis in the rat].[牛磺酸在大鼠实验性腹膜炎中的作用及副作用]
Langenbecks Arch Chir. 1986;368(3):149-62. doi: 10.1007/BF01261231.