Brañes L V, Kay W W
J Bacteriol. 1983 Jun;154(3):1462-6. doi: 10.1128/jb.154.3.1462-1466.1983.
Mutants resistant to several hydrophobic membrane antagonists were isolated from a "deep rough" (rfaC) mutant of Salmonella typhimurium. The resistance was due to an alteration in the core region lipopolysaccharide composition as evidenced by altered bacteriophage and complement sensitivity and by compositional analysis. The principal change in carbohydrate composition was the predominance of the unusual heptose isomer D-glycero-D-manno-heptose. The unusually wide pleiotropic phenotype of this organism is suggested to be due to a fundamental change in the properties of the bacterial outer membrane.
从鼠伤寒沙门氏菌的一个“深度粗糙”（rfaC）突变体中分离出了对几种疏水性膜拮抗剂具有抗性的突变体。这种抗性是由于核心区域脂多糖组成的改变，这一点通过噬菌体敏感性和补体敏感性的改变以及成分分析得到了证实。碳水化合物组成的主要变化是不寻常的庚糖异构体D-甘油-D-甘露庚糖占主导地位。这种生物体异常广泛的多效性表型被认为是由于细菌外膜性质的根本变化所致。
