Lee T H, Nagakura T, Papageorgiou N, Iikura Y, Kay A B
N Engl J Med. 1983 Jun 23;308(25):1502-5. doi: 10.1056/NEJM198306233082504.
Two adults and 13 children with exercise-induced asthma had both immediate and late reductions in forced expiratory volume in one second (FEV1) after treadmill exercise. The late reactions developed 4 to 10 hours after exercise and in each instance were associated with wheezing or chest tightness (or both). Increases in neutrophil chemotactic activity, measured in the 2 adults and in 11 of the children, accompanied the reductions in FEV1 in all these subjects. In contrast, four other adults with only an immediate fall in FEV1 after exercise had only an initial elevation in neutrophil chemotactic activity, with no subsequent increase for the remaining 24-hour period. The agent responsible for the neutrophil chemotactic activity released during exercise-induced late reactions appeared to be identical to that released during immediate reactions. These observations suggest that some patients with exercise-induced asthma have late reactions that, as in the case of antigen-induced bronchoconstriction, are accompanied by the release of neutrophil chemotactic activity.
两名成年患者和13名患有运动诱发性哮喘的儿童在跑步机运动后，一秒用力呼气量（FEV1）出现即刻和延迟降低。延迟反应在运动后4至10小时出现，且每次都伴有喘息或胸闷（或两者皆有）。在2名成人和11名儿童中检测到的中性粒细胞趋化活性增加，与所有这些受试者的FEV1降低同时出现。相比之下，另外四名运动后仅FEV1即刻下降的成人，中性粒细胞趋化活性仅最初升高，在随后的24小时内没有进一步增加。运动诱发的延迟反应期间释放的负责中性粒细胞趋化活性的介质，似乎与即刻反应期间释放的介质相同。这些观察结果表明，一些运动诱发性哮喘患者会出现延迟反应，如同抗原诱发的支气管收缩一样，伴有中性粒细胞趋化活性的释放。
