[Interrelationship between activity of nuclear ribonucleotide reductase and DNA synthesis of hepatocyte nuclei during liver tissue regeneration].

Dynamics of 3H-thymidine incorporation into nuclear DNA and activity of nuclear ribonucleotide reductase were studied within 2 days after partial hepatectomy. The curves describing dynamics of DNA synthesis and the activity of ribonucleotide reductase were of wave-shaped pattern. Maximal enzymatic activity was reached 2 hrs before the nuclear DNA synthesis maximum. An inhibitor of ribonucleotide reductase was found in the globulin fraction of intact liver nuclei; after addition of the inhibitor the activity of the enzyme was decreased 4-5-fold, if the ratio of protein in preparations inhibitor/enzyme was as high as 1:40.