Wilhelmsson L, Lindblom B, Wikland M, Hamberger L, Norström A, Wiqvist N
Acta Obstet Gynecol Scand Suppl. 1983;113:69-70.
Small longitudinally or helically cut strips from the ascending branch of the uterine artery were mounted in organ chambers for isometric recording of contractile activity. PGI2(3-300 ng/ml) caused a concentration-dependent relaxation of spontaneously active preparations, whereas no inhibitory effect could be observed on non-active strips. Furthermore, the compound counteracted the stimulatory effects of PGE2, PGF2 alpha, and NA, but not that of transmural nerve stimulation. The effect of PGI2 could be of interest in that the compound may balance the action of vasoconstricting agents. A disturbance of this balance may be a hitherto unrecognized contributing pathophysiological mechanism in the development of dysmenorrhea.
从子宫动脉升支纵向或螺旋状切取的小条组织被安装在器官浴槽中，用于等长记录收缩活动。前列环素（PGI2，3 - 300 ng/ml）可使自发活动的标本产生浓度依赖性舒张，而对无活性的组织条未观察到抑制作用。此外，该化合物可对抗前列腺素E2、前列腺素F2α和去甲肾上腺素的刺激作用，但不能对抗跨壁神经刺激的作用。PGI2的作用可能具有重要意义，因为该化合物可能平衡血管收缩剂的作用。这种平衡的紊乱可能是痛经发生发展中一种迄今未被认识的病理生理机制。
