Mielke C H
Am J Med. 1983 Jun 14;74(6A):72-8. doi: 10.1016/0002-9343(83)90532-6.
Aspirin influences the bleeding time, presumably through the inhibition of prostaglandin biosynthesis and the resultant platelet secretion reaction. This can be measured by prolongation of the bleeding time and changes in platelet function results. Despite these changes, bleeding is rarely a problem in patients who have normal hemostatic mechanisms. To investigate this, we have studied the technical variables associated with the determination of the bleeding time. Both venostasis and direction of the incision play a major role in the bleeding time prolongation induced by aspirin. When a bleeding time determination is performed with vertical incision without venostasis, there is almost no detectable prolongation of the bleeding time. These studies support our previous observations that aspirin has a mild influence on primary hemostasis.
阿司匹林可能通过抑制前列腺素生物合成及由此产生的血小板分泌反应来影响出血时间。这可通过出血时间的延长和血小板功能结果的变化来衡量。尽管有这些变化，但对于具有正常止血机制的患者来说，出血很少成为问题。为了对此进行研究，我们研究了与出血时间测定相关的技术变量。静脉淤滞和切口方向在阿司匹林引起的出血时间延长中都起主要作用。当在没有静脉淤滞的情况下进行垂直切口的出血时间测定时，几乎检测不到出血时间的延长。这些研究支持了我们之前的观察结果，即阿司匹林对初级止血有轻微影响。
