Neilson D R, Prins R P, Bolton R N, Mark C, Watson P
Am J Obstet Gynecol. 1983 Jul 1;146(5):526-32. doi: 10.1016/0002-9378(83)90795-0.
The unfavorable cervix remains a major obstacle to the successful induction of labor. Reported are results from an ongoing study of topical prostaglandin preparations used to effect preinduction cervical ripening. The current study compares the efficacy of 40 mg of prostaglandin (PG) F2 alpha versus 5 mg of PGE2, applied to the cervix in a methyltylose gel the night before attempted induction of labor. A prospective double-blind protocol was used similar to that which previously established the efficacy of the 5 mg of PGE2 preparation versus placebo at this institution. Results indicate the superiority of the PGE2 preparation as measured by change in Bishop score, Pitocin requirement, rate of cervical dilatation, and percentage of failed inductions. Cesarean section rates were similar in the two study groups, and no fetal or maternal morbidity was attributable to the preinduction ripening technique.
不利的宫颈状况仍然是成功引产的主要障碍。本文报告了一项正在进行的关于用于引产术前宫颈成熟的局部前列腺素制剂研究的结果。当前研究比较了40毫克前列腺素（PG）F2α与5毫克PGE2的疗效，在引产术前一晚将其以甲基纤维素凝胶的形式应用于宫颈。采用了前瞻性双盲方案，类似于此前在本机构确定5毫克PGE2制剂与安慰剂疗效对比的方案。结果表明，以 Bishop评分变化、催产素需求量、宫颈扩张率和引产失败率衡量，PGE2制剂更具优势。两个研究组的剖宫产率相似，且引产术前成熟技术未导致任何胎儿或母体发病情况。
