[阿霉素对免疫发生的作用]
[Action of doxorubicin on immunogenesis].
作者信息
Shapovalova S P, Malkova I V
出版信息
Antibiotiki. 1983 Apr;28(4):304-7.
PMID:6344783
Abstract
The effect of doxorubicin, carminomycin and rubomycin on some immunological reactions was studied comparatively on mice. It was shown that doxorubicin had an immunodepressant effect on the synthesis of antibodies and antibody-forming cells. By the character of its immunodepressant effect doxorubicin was similar to rubomycin. In a dose of 0.3 of the LD50 doxorubicin had no effect on the transplantation immunity in the system of "transplant versus host" and did not prolong the lifetime of the skin graft.
摘要
比较研究了阿霉素、洋红霉素和柔红霉素对小鼠某些免疫反应的影响。结果表明，阿霉素对抗体和抗体形成细胞的合成具有免疫抑制作用。就其免疫抑制作用的特点而言，阿霉素与柔红霉素相似。以半数致死量（LD50）的0.3剂量，阿霉素对“移植对宿主”系统中的移植免疫没有影响，也没有延长皮肤移植物的存活时间。
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[Action of doxorubicin on immunogenesis].[阿霉素对免疫发生的作用]
Antibiotiki. 1983 Apr;28(4):304-7.
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