BW 245C（依前列醇（PGI2）的一种稳定类似物）对人体心血管和血小板的影响。
Cardiovascular and platelet effects in man of BW 245C, a stable mimic of epoprostenol (PGI2).
作者信息
Orchard M A, Ritter J M, Shepherd G L, Lewis P J
出版信息
Br J Clin Pharmacol. 1983 May;15(5):509-11. doi: 10.1111/j.1365-2125.1983.tb02083.x.
Abstract
1 BW 245C is a stable hydantoin prostaglandin analogue with a biological action similar to epoprostenol (PGI2). 2 Intravenous BW 245C (1,2 and 4 ng kg-1 min-1) produced a progressive increase in heart rate and pulse pressure in four healthy male volunteers. 3 These changes in heart rate and pulse pressure were accompanied by reduced ex vivo platelet aggregation to submaximal concentrations of ADP. 4 In man, BW 245C has a profile of action and potency similar to PGI2. However, it has a longer duration of action than PGI2.
摘要
- BW 245C是一种稳定的乙内酰脲前列腺素类似物，其生物活性与依前列醇（前列环素I2）相似。2. 对4名健康男性志愿者静脉注射BW 245C（1、2和4纳克/千克/分钟）后，心率和脉压逐渐升高。3. 心率和脉压的这些变化伴随着离体血小板对亚最大浓度ADP的聚集减少。4. 在人体中，BW 245C的作用模式和效力与前列环素I2相似。然而，其作用持续时间比前列环素I2更长。
相似文献
1
Cardiovascular and platelet effects in man of BW 245C, a stable mimic of epoprostenol (PGI2).BW 245C（依前列醇（PGI2）的一种稳定类似物）对人体心血管和血小板的影响。
Br J Clin Pharmacol. 1983 May;15(5):509-11. doi: 10.1111/j.1365-2125.1983.tb02083.x.
2
Effects of single oral dose administration of a hydantoin prostaglandin analogue BW 245C in man.海因妥因前列腺素类似物BW 245C单次口服给药对人体的影响。
Life Sci. 1984 Jun 4;34(23):2281-6. doi: 10.1016/0024-3205(84)90218-2.
3
Inhibition of platelet aggregation with intravenous and oral administration of carboprostacyclin in man.静脉内和口服卡前列环素对人体血小板聚集的抑制作用。
Prostaglandins Med. 1981 May;6(5):521-7. doi: 10.1016/0161-4630(81)90112-9.
4
Single-blind study of epoprostenol and 6-keto-prostaglandin E1 in man: effects of platelet aggregation and plasma renin.依前列醇和6-酮-前列腺素E1在人体中的单盲研究：对血小板聚集和血浆肾素的影响
Br J Clin Pharmacol. 1985 Dec;20(6):681-3. doi: 10.1111/j.1365-2125.1985.tb05128.x.
5
Noninvasive assessment of the cardiovascular effects of prostacyclin (PGI2) in man.前列环素（PGI2）对人体心血管作用的无创评估。
Eur J Cardiol. 1980;12(2):73-80.
6
Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets.前列腺素D2与前列环素、卡前列环素及乙内酰脲前列腺素BW245C在豚鼠血小板中的相互作用。
Br J Pharmacol. 1985 May;85(1):285-90. doi: 10.1111/j.1476-5381.1985.tb08858.x.
7
The cardiovascular and platelet actions of 9 beta-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey.9β-甲基前列环素（西前列烯）是前列环素的一种化学稳定类似物，对犬和猴的心血管及血小板作用。
Br J Pharmacol. 1985 Jun;85(2):547-55. doi: 10.1111/j.1476-5381.1985.tb08892.x.
8
Effects of intravenous epoprostenol on platelets and the cardiovascular system are not potentiated by dipyridamole.双嘧达莫不会增强静脉注射依前列醇对血小板和心血管系统的作用。
Clin Pharmacol Ther. 1983 Feb;33(2):178-82. doi: 10.1038/clpt.1983.27.
9
On the multiplicity of platelet prostaglandin receptors. II. The use of N-0164 for distinguishing the loci of action for PGI2, PGD2, PGE2 and hydantoin analogs.血小板前列腺素受体的多样性。II. N-0164在区分前列环素、前列腺素D2、前列腺素E2和乙内酰脲类似物作用位点方面的应用。
Prostaglandins. 1984 May;27(5):683-96. doi: 10.1016/0090-6980(84)90007-8.
10
A chemically stable analogue, 9 beta-methyl carbacyclin, with similar effects to epoprostenol (prostacyclin, PGI2) in man.一种化学性质稳定的类似物，9β-甲基卡前列环素，在人体内具有与依前列醇（前列环素，PGI2）相似的作用。
Br J Clin Pharmacol. 1984 Dec;18(6):921-33. doi: 10.1111/j.1365-2125.1984.tb02565.x.
引用本文的文献
1
Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1.前列腺素D2受体DP1的配体识别与受体激活的分子基础
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2501902122. doi: 10.1073/pnas.2501902122. Epub 2025 May 29.
2
Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.参与调节新生大鼠心肌细胞跳动频率的前列腺素受体。
PLoS One. 2012;7(9):e45273. doi: 10.1371/journal.pone.0045273. Epub 2012 Sep 12.
3
Characterization of the inhibitory prostanoid receptors on human neutrophils.人中性粒细胞上抑制性前列腺素受体的特性分析。
Br J Pharmacol. 1993 Apr;108(4):1051-4. doi: 10.1111/j.1476-5381.1993.tb13504.x.
4
A chemically stable analogue, 9 beta-methyl carbacyclin, with similar effects to epoprostenol (prostacyclin, PGI2) in man.一种化学性质稳定的类似物，9β-甲基卡前列环素，在人体内具有与依前列醇（前列环素，PGI2）相似的作用。
Br J Clin Pharmacol. 1984 Dec;18(6):921-33. doi: 10.1111/j.1365-2125.1984.tb02565.x.
5
Effects of a stable prostaglandin analogue, L-644,122, in healthy and hypertensive men.稳定前列腺素类似物L-644,122对健康男性和高血压男性的影响。
Eur J Clin Pharmacol. 1985;28(6):685-8. doi: 10.1007/BF00607916.
6
The effect of a prostaglandin DP-receptor partial agonist (192C86) on platelet aggregation and the cardiovascular system in healthy volunteers.前列腺素DP受体部分激动剂（192C86）对健康志愿者血小板聚集及心血管系统的影响。
Br J Clin Pharmacol. 1992 Oct;34(4):344-51. doi: 10.1111/j.1365-2125.1992.tb05641.x.
本文引用的文献
1
Aggregation of blood platelets by adenosine diphosphate and its reversal.二磷酸腺苷引起的血小板聚集及其逆转
Nature. 1962 Jun 9;194:927-9. doi: 10.1038/194927b0.
2
Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man.依前列醇（前列环素，PGI2）在人体给药期间出现的副作用。
Br J Clin Pharmacol. 1982 Aug;14(2):177-85. doi: 10.1111/j.1365-2125.1982.tb01959.x.
3
Prostaglandin influence on pulmonary intravascular leukocytic aggregation during cardiopulmonary bypass.前列腺素对体外循环期间肺血管内白细胞聚集的影响。
J Thorac Cardiovasc Surg. 1977 Feb;73(2):221-4.
4
A double blind placebo controlled crossover study of prostacyclin in man.一项关于前列环素在人体中的双盲安慰剂对照交叉研究。
Life Sci. 1979 Aug 20;25(8):665-72. doi: 10.1016/0024-3205(79)90507-1.
5
Successful therapy of advanced arteriosclerosis obliterans with prostacyclin.前列环素成功治疗晚期闭塞性动脉硬化症
Lancet. 1979 May 26;1(8126):1111-4. doi: 10.1016/s0140-6736(79)91792-6.
Zotero 插件