Warrington S J, Smith P R, O'Grady J
Eur J Cardiol. 1980;12(2):73-80.
The cardiovascular actions of prostacyclin (PGI2) were investigated in a double-blind, randomised, balanced study. Six healthy volunteers received intravenous infusions of PGI2 in a range of doses up to 4 ng/kg per min, which is the lowest dose which consistently inhibits platelet aggregation. Measurements of systolic time intervals, peak normalised first derivative of the apexcardiogram, high-speed surface electrocardiogram and arterial blood pressure were made during each infusion. PGI2 caused dose-related decreases in diastolic blood pressure, preejection period and QS2 index, and an increase in heart rate. Systolic blood pressure, left ventricular ejection time index, the peak normalised first derivative of the apexcardiogram, and PR interval, QRS duration, QT index and T-wave amplitude were unchanged. Facial flushing was seen in all subjects at PGI2 4 ng/kg per min. These results suggest that PGI2 has an important arteriolar vasodilator action, but do not exclude a minor direct effect on contractility.
在一项双盲、随机、平衡研究中对前列环素（PGI2）的心血管作用进行了研究。6名健康志愿者接受了剂量高达每分钟4 ng/kg的PGI2静脉输注，这是持续抑制血小板聚集的最低剂量。在每次输注期间，测量收缩期时间间期、心尖搏动图的峰值归一化一阶导数、高速体表心电图和动脉血压。PGI2导致舒张压、射血前期和QS2指数呈剂量相关下降，心率增加。收缩压、左心室射血时间指数、心尖搏动图的峰值归一化一阶导数以及PR间期、QRS时限、QT指数和T波振幅均未改变。在PGI2为每分钟4 ng/kg时，所有受试者均出现面部潮红。这些结果表明，PGI2具有重要的小动脉血管舒张作用，但不排除对收缩性有轻微的直接影响。
