Jeremy J Y, Tsang V, Mikhailidis D P, Rogers H, Morgan R J, Dandona P
Br J Urol. 1987 Jan;59(1):36-9. doi: 10.1111/j.1464-410x.1987.tb04575.x.
Biopsies of human urinary bladder mucosa obtained during cystoscopy were shown to release eicosanoids in the following order: prostacyclin (PGI2), prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha) and thromboxane A2 (TXA2). The total and the relative amounts of eicosanoids released were similar to those reported for the rat urinary bladder. These eicosanoids may play a role in modulating the tone and contractility of the bladder as well as affecting cytoprotection of the mucosa. In view of the abundant release of eicosanoids by the bladder, caution must be exercised when considering urinary eicosanoid excretion as reflecting production by the systemic vasculature and/or the kidneys.
膀胱镜检查时获取的人膀胱黏膜活检标本显示，类花生酸的释放顺序如下：前列环素（PGI2）、前列腺素E2（PGE2）、前列腺素F2α（PGF2α）和血栓素A2（TXA2）。类花生酸的总释放量和相对释放量与大鼠膀胱的报道相似。这些类花生酸可能在调节膀胱张力和收缩性以及影响黏膜细胞保护方面发挥作用。鉴于膀胱大量释放类花生酸，在将尿类花生酸排泄视为反映全身血管系统和/或肾脏的生成时必须谨慎。
