McNeilage L J, Heslop B F
Cell Immunol. 1983 Jun;78(2):206-16. doi: 10.1016/0008-8749(83)90275-7.
In some strain combinations among inbred rats intravenously injected 51Cr-labeled lymphocytes are rapidly destroyed in substantial numbers by unsensitized allogeneic hosts. This phenomenon has been referred to as natural cytotoxicity (NC) and is characterized by decreased lymph node radioactivity, increased kidney and urine radioactivity, and to a lesser extent increased liver radioactivity in allogeneic hosts, when compared with the distribution of label in syngeneic recipients of the same cell suspension. A single exposure to 800 rad either 1 or 7 days before the injection of 51Cr-labeled lymphocytes effected a reduction in NC as defined by all the above parameters in a strain combination exhibiting high NC. The same dosage of radiation abolished NC in a strain combination exhibiting intermediate leads to low NC. Because NC was not always completely abolished, the phenomenon was held to be partially radiosensitive. An increased accumulation of 51Cr-labeled lymphocytes was seen in the lymph nodes of both syngeneic and allogeneic irradiated hosts when compared with nonirradiated controls, although the increase was greater in allogeneic than in syngeneic hosts. This increased colonization in the lymph nodes of irradiated hosts seemed unlikely to be due to an increase in the available "space' in the lymph nodes following irradiation.
在一些近交系大鼠的品系组合中，静脉注射51Cr标记淋巴细胞后，未致敏的同种异体宿主会大量快速破坏这些淋巴细胞。这种现象被称为自然细胞毒性（NC），其特征是与同基因受体接受相同细胞悬液后标记物的分布相比，同种异体宿主的淋巴结放射性降低、肾脏和尿液放射性增加，肝脏放射性也有较小程度的增加。在注射51Cr标记淋巴细胞前1天或7天单次暴露于800拉德辐射，会使表现出高NC的品系组合中的NC（根据上述所有参数定义）降低。相同剂量的辐射消除了表现出中等至低NC的品系组合中的NC。由于NC并非总是完全消除，因此认为该现象部分对辐射敏感。与未照射的对照相比，在同基因和同种异体照射宿主的淋巴结中均可见51Cr标记淋巴细胞的积累增加，尽管同种异体宿主中的增加幅度大于同基因宿主。照射宿主淋巴结中这种增加的定植似乎不太可能是由于照射后淋巴结中可用“空间”增加所致。
