Gebhardt C, Stolte M, Schwille P O, Zirngibl H, Engelhardt W
Horm Metab Res Suppl. 1983(13):9-11.
The effect of the occlusion of the pancreatic duct system with prolamine (Ethibloc) has been studied in animal experiments with dogs and mini-pigs. The solution becomes solid in the duct system and becomes disintegrated again within 11 days. This time, however, is sufficient to keep a high-grade atrophy of the exocrine parenchyma. With this method one doesn't risk the provocation of an acute pancreatitis. The endocrine function of the atrophied glands is satisfactory, no animal became diabetic. The basal jugular vein insulin shows no difference to that of the control group, but nevertheless the mean whole pancreas hormone content is reduced for insulin and somatostatin, but not for glucagon.
在犬类和小型猪的动物实验中，研究了用醇溶蛋白（Ethibloc）阻塞胰腺导管系统的效果。该溶液在导管系统中会凝固，并在11天内再次分解。然而，这段时间足以使外分泌实质保持高度萎缩状态。用这种方法不会引发急性胰腺炎。萎缩腺体的内分泌功能良好，没有动物出现糖尿病。颈静脉基础胰岛素水平与对照组无差异，但整个胰腺中胰岛素和生长抑素的激素平均含量降低，而胰高血糖素的含量未降低。
