Monaco G, Riccardelli F, Lirici M M, Palmieri G, D'Angelo F, Ragusa M, Federico F, Paolini A
Ital J Surg Sci. 1984;14(2):125-9.
Prolamine is an alcoholic solution of zein, with the property of polymerizing within 15 minutes in a humid medium. Such a substance has been injected in the pancreatic duct of 10 pigs with a microsurgical technique, causing complete occlusion. The prolamine gel produces a progressive fibrosclerosis of the exocrine pancreatic parenchyma, sparing the endocrine portion. The resulting pancreatic atrophy avoids the occurrence of inflammatory complications that often hamper surgery on such gland. The 10 pigs under study showed post-operative normal values of blood glucose and insulin, and a decrease in serum alpha-amylase levels. Complications occurred in only one case, and the microscopic pattern was similar in all cases. Microsurgical approach and use of prolamine are considered effective both in pancreatic transplantation and in chronic pancreatitis.
醇溶谷蛋白是玉米醇溶蛋白的酒精溶液，具有在潮湿介质中15分钟内聚合的特性。已采用显微外科技术将这种物质注入10头猪的胰管，导致完全阻塞。醇溶谷蛋白凝胶会使胰腺外分泌实质逐渐发生纤维硬化，而内分泌部分不受影响。由此产生的胰腺萎缩可避免经常妨碍该腺体手术的炎症并发症的发生。所研究的10头猪术后血糖和胰岛素值正常，血清α淀粉酶水平降低。仅1例发生并发症，所有病例的微观模式相似。显微外科手术方法和醇溶谷蛋白的使用在胰腺移植和慢性胰腺炎中均被认为是有效的。
