Drewes S E, Magojo H E, Gliemann J
Hoppe Seylers Z Physiol Chem. 1983 Apr;364(4):461-8. doi: 10.1515/bchm2.1983.364.1.461.
Reaction of 2-iodo-N-methylpyridinium iodide with insulin gave, amongst others, A19- and B16-(N-methylpyridinium)insulin derivatives in which the phenolic groups of the respective tyrosines had been modified. Under carefully controlled conditions the A19 derivative gave small rhombohedral crystals, whereas the B16 derivative failed to crystallize. Both these derivatives had low biological activities.
2-碘-N-甲基吡啶碘化物与胰岛素反应，除其他产物外，还生成了A19-和B16-(N-甲基吡啶鎓)胰岛素衍生物，其中相应酪氨酸的酚羟基已被修饰。在严格控制的条件下，A19衍生物形成了小的菱面体晶体，而B16衍生物未能结晶。这两种衍生物的生物活性都很低。
