同基因和自体骨髓重建后环孢素A治疗大鼠的移植物抗宿主病
Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.
作者信息
Glazier A, Tutschka P J, Farmer E R, Santos G W
出版信息
J Exp Med. 1983 Jul 1;158(1):1-8. doi: 10.1084/jem.158.1.1.
Abstract
Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.
摘要
用环孢素A（CsA）治疗20 - 40天的致死性辐照大鼠，在停用CsA并用同基因或自体骨髓重建后会发生典型的移植物抗宿主病（GVHD），而正常大鼠则不会。同基因GVHD可转移至经辐照但非同基因的正常受体。正常脾细胞无法预防同基因GVHD的发生或过继转移。
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