十四烷基硫酸钠对家兔的抗生育作用。

Antifertility effects of tetradecyl sodium sulphate in rabbits.

作者信息

Zimmerman R E, Nevin R S, Allen D J, Jones C D, Goettel M E, Burck P J

出版信息

J Reprod Fertil. 1983 Jul;68(2):257-63. doi: 10.1530/jrf.0.0680257.

DOI:10.1530/jrf.0.0680257

Abstract

Acrosin and acrosomal hyaluronidase were inhibited by tetradecyl sodium sulphate (TDSS) in vitro at concentrations of less than 10(-4) M. TDSS prevented the removal in vitro of the cumulus oophorus by testicular hyaluronidase and the zona pellucida by acrosin. TDSS had a contraceptive effect in rabbits when administered intravaginally before coitus or released at levels of 1-3 micrograms/day from intrauterine silicone rubber devices.

摘要

十四烷基硫酸钠（TDSS）在体外浓度低于10⁻⁴ M时可抑制顶体蛋白酶和顶体透明质酸酶。TDSS可在体外阻止睾丸透明质酸酶去除卵丘以及顶体蛋白酶去除透明带。在兔身上，TDSS在性交前经阴道给药或通过宫内硅橡胶装置以每天1 - 3微克的水平释放时具有避孕作用。