Hytönen S, Alfheim I, Sorsa M
Mutat Res. 1983 Jul;118(1-2):69-75. doi: 10.1016/0165-1218(83)90117-9.
The SCE-induction capacity of emissions from an airtight horizontal baffled residential wood stove was investigated in CHO cells. The samples were taken under normal and starved air conditions, from burning birch and spruce separately. Both particle phase and vapour phase were collected. All samples induced a dose-related response in SCE both with and without a metabolic activation system, the rat-liver microsomal fraction. The burning conditions in the stove influenced the mutagenicity of the emissions more than the type of wood; the smoke from wood burning under starved air conditions was more than one order of magnitude more potent in inducing a significant SCE response. With all samples, the response in SCE induction was highest without metabolic activation. The toxicity of the samples, especially those without S9, limited the dose-range tested.
在CHO细胞中研究了密闭式水平折流住宅木炉排放物的姐妹染色单体交换（SCE）诱导能力。分别在正常空气条件和空气不足条件下，对燃烧桦木和云杉产生的排放物进行采样。同时收集了颗粒相和气相物质。无论有无代谢激活系统（大鼠肝脏微粒体部分），所有样品均在SCE中诱导出剂量相关反应。与木材种类相比，炉内的燃烧条件对排放物的致突变性影响更大；在空气不足条件下燃烧木材产生的烟雾在诱导显著SCE反应方面的效力要高出一个数量级以上。对于所有样品，在没有代谢激活的情况下，SCE诱导反应最高。样品的毒性，尤其是那些不含S9的样品，限制了测试的剂量范围。
