Chance William T, Krynock Glenn M, Rosecrans John A
Department of Pharmacology, Medical College of Virginia, Richmond, Va. 23298 U.S.A.
Pain. 1978 Feb;4(3):243-252. doi: 10.1016/0304-3959(77)90136-1.
Hyperemotionality and antinociception (during hyperemotional states) followed lesioning of the septal area in rats. Both of these behaviors showed parallel decreases with daily handling as well as significant positive correlations between them. Tail-flick latencies were also elevated when fear was conditioned to the environmental cues associated with the tail-flick procedure. Fear-induced antinociception trials. These results are interpreted as demonstrations of the behavioral activation of endogenous antinociceptive mechanisms and are in agreement with the postulates of centrifugal control of nociception of the gate control theory of pain.
大鼠的隔区损伤后出现了情绪过度激动和抗伤害感受（在情绪过度激动状态下）。这两种行为都随着每日的处理而平行减少，并且它们之间存在显著的正相关。当恐惧与甩尾程序相关的环境线索形成条件反射时，甩尾潜伏期也会延长。恐惧诱导的抗伤害感受试验。这些结果被解释为内源性抗伤害感受机制行为激活的证明，并且与疼痛闸门控制理论中伤害感受的离心控制假设一致。
