Buchbauer G, Esterer S, Cermak C
Pharmazie. 1983 Mar;38(3):151-69.
This review compiles the literature about norbornanes which already are used as medicaments and such bicyclo [2.2.1]heptanes, which are connected with drug research in some way. As is shown for the period from 1967 until 1980 the occupation with these bicyclic compounds has gained some importance in drug research, not only because they are used medicinally but also because they are used as suitable test molecules for studying structure-activity-relationships by reason of their special molecular shape, their voluminous, bicyclic carbon skeleton and the sterically fixed position of their substituents.
本综述汇编了有关已用作药物的降冰片烷以及以某种方式与药物研究相关的双环[2.2.1]庚烷的文献。正如1967年至1980年期间所显示的那样，对这些双环化合物的研究在药物研究中已变得有些重要，这不仅是因为它们被药用，还因为由于其特殊的分子形状、庞大的双环碳骨架以及取代基的空间固定位置，它们被用作研究构效关系的合适测试分子。
