Buchbauer G, Spreitzer H, Püringer C
Institut für Pharmazeutische Chemie der Universität, Wien.
Arch Pharm (Weinheim). 1990 Jun;323(6):367-73. doi: 10.1002/ardp.19903230609.
Starting from the corresponding amines the syntheses of various norbornyl ureas with potential fungicidal activity are described. These new compounds possess a tricyclo[5.2.1.0(2,6)]decane, or an isocamphenilane, a camphenilane, an exo- and endo- dimethylnorbornane or a bicyclo[2.2.2]octane carbon skeleton. With the exception of the first class all other derivatives bear a geminal dimethyl group--important because of its shielding effect--at C-3 of the bicyclus. Some ureas, especially 6 and the acetamide 5, are active against phytopathogenic fungi.
本文描述了从相应胺类出发合成具有潜在杀真菌活性的各种降冰片基脲的方法。这些新化合物具有三环[5.2.1.0(2,6)]癸烷、异莰菲烷、莰菲烷、外型和内型二甲基降冰片烷或双环[2.2.2]辛烷碳骨架。除第一类外，所有其他衍生物在双环的C-3位带有偕二甲基基团——由于其屏蔽效应而很重要。一些脲类，特别是6和乙酰胺5，对植物病原真菌有活性。
