反复高剂量使用纳洛酮治疗对精神分裂症患者无效。

Pharmacopsychiatria. 1983 Mar;16(2):43-5. doi: 10.1055/s-2007-1017446.

6 schizophrenic patients were treated in a cross-over design for 4 days each with 20 mg naloxone or placebo. No patient showed a significant change of his or her psychotic behaviour. This result is not in agreement with an antipsychotic action of the opiate antagonist.

6名精神分裂症患者采用交叉设计，分别接受20毫克纳洛酮或安慰剂治疗，各为期4天。没有患者的精神病行为出现显著变化。这一结果与阿片类拮抗剂的抗精神病作用不符。