在II区和III区条件下固定的肺中弥散能力的形态学估计。
Morphometric estimates of diffusing capacity in lungs fixed under zone II and zone III conditions.
作者信息
Bachofen H, Weber J, Wangensteen D, Weibel E R
出版信息
Respir Physiol. 1983 Apr;52(1):41-52. doi: 10.1016/0034-5687(83)90135-4.
Comparative morphometric estimates of the diffusing capacity (DL) were made in rabbit lungs fixed by vascular perfusion under lower zone II and zone III conditions and in lungs fixed by instillation of fixatives into the airways. Owing to a reduction of both capillary volume and membrane diffusing capacity DL of zone II lungs (0.074 +/- 0.007 (SD) ml . sec-1 . mbar-1). was found to be lower by some 25% than DL of instillation-fixed lungs (0.102 +/- 0.012 (SD) ml . sec-1 . mbar-1). The average value of DL of air-filled zone III lungs, on the other hand, almost matched the DL of instillation-fixed lungs. However, DL is not equal in all regions but increases along the vertical axis of zone III lungs. Hence, the previous conclusion that morphometric estimates of DL in instillation-fixed lungs reflects a structural limit for O2 diffusion, which cannot be reached under physiologic conditions, must be revised.
在通过血管灌注固定于下肺二区和三区条件下的兔肺以及通过向气道内滴注固定剂固定的兔肺中，对弥散能力（DL）进行了比较形态学评估。由于二区肺的毛细血管容积和膜弥散能力DL均降低（0.074±0.007（标准差）ml·sec⁻¹·mbar⁻¹），发现其比滴注固定肺的DL（0.102±0.012（标准差）ml·sec⁻¹·mbar⁻¹）低约25%。另一方面，充气的三区肺的DL平均值几乎与滴注固定肺的DL相匹配。然而，DL在所有区域并不相等，而是沿三区肺的垂直轴增加。因此，先前关于滴注固定肺中DL的形态学评估反映了氧气扩散的结构极限（在生理条件下无法达到）这一结论必须修正。
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