Nanu L, Marcean-Petrescu R, Stefănescu A M
Endocrinologie. 1983 Apr-Jun;21(2):99-104.
To determine the processes of adrenaline and noradrenaline secretion-excretion in rats and rabbits with/without associated insulin lente administration (20 U.I./kg rat b.w. and 6 U.I./kg rabbit b.w.), the authors used a pineal peptide extract that has now become available under the trade name of "Crinofizin". Under conditions of natural light, environmental temperature of 18-20 degrees C and fed ad libitum, Crinofizin did not cause significant alterations in the rat 24 hrs urinary excretion of catecholamines. Administration of insulin induced a more than two-fold increase in the two catecholamines both in the rabbit and the rat. Administration of Crinofizin one hour before insulin prevented totally or partially these effects of insulin. The drug acted as a blocking agent in the processes of endogenous adrenaline and noradrenaline secretion-excretion under hormonal stimulation, but not under basal conditions.
为了确定给予或未给予低精蛋白胰岛素（大鼠体重20单位国际单位/千克，兔体重6单位国际单位/千克）的大鼠和兔体内肾上腺素和去甲肾上腺素的分泌-排泄过程，作者使用了一种松果体肽提取物，该提取物现以“Crinofizin”的商品名上市。在自然光照、环境温度为18-20摄氏度且随意进食的条件下，Crinofizin并未导致大鼠24小时儿茶酚胺尿排泄量发生显著变化。给予胰岛素后，兔和大鼠体内这两种儿茶酚胺的排泄量均增加了两倍多。在胰岛素给药前1小时给予Crinofizin可完全或部分预防胰岛素的这些作用。该药物在激素刺激下内源性肾上腺素和去甲肾上腺素分泌-排泄过程中起阻断剂作用，但在基础条件下不起作用。
