Auriol M, Ragot J, Chomette G
Rev Stomatol Chir Maxillofac. 1983;84(3):162-6.
A 5.1/2-year-old girl presented with an isolated diffuse gingival hypertrophy and an abnormal mobility of teeth (alveolysis on roentgenograms). The diagnosis of a plasmacytoma was suspected after pathological and immunohistological examinations of a gingival biopsy. Plasma cells were secreting monoclonal immunoglobulins (heavy chain IgA and light chain lambda), quite different from polyclonal secretions of a reactive plasmacytosis. The electron microscopic study demonstrated polymorphic plasma cells (well-differentiated, dysplastic or undifferentiated cells). The isolated nature of this tumor was confirmed by biological tests and radiological investigations. The extremely rare diffuse gingival locations of extraosseous solitary plasmacytomas was proved by a review of the published litterature. The evolution of such gingival tumors is unknown. It seems to be variable, and, perhaps, diffuse myelomas may develop later on (as in other sites of extra-osseous solitary plasmacytoma).
一名5岁半女童出现孤立性弥漫性牙龈肥大及牙齿异常松动（X线片显示牙槽骨吸收）。牙龈活检经病理及免疫组织学检查后怀疑为浆细胞瘤。浆细胞分泌单克隆免疫球蛋白（重链IgA和轻链λ），与反应性浆细胞增多症的多克隆分泌截然不同。电镜研究显示为多形性浆细胞（分化良好、发育异常或未分化细胞）。生物学检测及放射学检查证实了该肿瘤的孤立性。通过查阅已发表文献证实了骨外孤立性浆细胞瘤极其罕见的弥漫性牙龈发病部位。此类牙龈肿瘤的病程尚不清楚。其似乎具有多变性，或许之后可能会发展为弥漫性骨髓瘤（如同骨外孤立性浆细胞瘤的其他发病部位）。
