Voirol M, Stalder G A, Fasel J, Séchaud R, Desbaillets L G, Kapp F, Krieg P, Aenishänslin H W, Wyss G
Schweiz Med Wochenschr. 1983 Apr 30;113(17):643-5.
In the context of a cooperative clinical trial carried out in the Cantons of Basel and Vaud, Switzerland, the litholytic effect of ursodeoxycholic acid (Ursochol) in a daily dose of 9 mg/kg was investigated in 42 patients with radiotransparent gallstones. The litholytic effect was evident in 22 (73%) of the 30 patients followed up for a maximum period of 1 year. Complete dissolution of gallstones was obtained in 40% of cases. In addition, ursodeoxycholic acid significantly reduced (p less than 0,001) the dyspeptic-painful symptoms and the number of biliary colics. Tolerance was excellent. In particular, no cases of diarrhea were observed.
在瑞士巴塞尔州和沃州进行的一项合作临床试验中，对42例透X线胆结石患者研究了每日剂量为9 mg/kg的熊去氧胆酸（优思弗）的溶石效果。在随访最长达1年的30例患者中，22例（73%）有明显溶石效果。40%的病例胆结石完全溶解。此外，熊去氧胆酸显著减轻（p<0.001）消化不良性疼痛症状和胆绞痛发作次数。耐受性良好。特别是，未观察到腹泻病例。
