Realini S, Gonvers J J, Arnold J, Borel G A, Bretholz A, Capitaine Y, Hofstetter J R, Bettini L, di Simone A
Schweiz Med Wochenschr. 1983 Apr 30;113(17):641-2.
51 patients with radiolucent gallstones of diameter less than or equal to 15 mm were treated for 6 months with a new form of ursodeoxycholic acid (UDCA) in a single dose of 450 mg at bedtime. This new form has 3 components with fractionate liberation. The rate of partial and complete dissolution after 6 months was 63.4%, reaching 85% for gallstones of less than 5 mm diameter. The results show that a single dose of 450 mg UDCA at bedtime is as effective as UDCA at mealtimes in the dissolution of radiolucent gallstones. Administration of the drug once a day should be more acceptable to patients.
51例直径小于或等于15毫米的透X线胆结石患者接受了一种新型熊去氧胆酸（UDCA）治疗，剂量为450毫克，每晚睡前单次服用，为期6个月。这种新型药物有3种成分，可分次释放。6个月后部分溶解和完全溶解的比例为63.4%，直径小于5毫米的胆结石溶解率达到85%。结果表明，每晚睡前单次服用450毫克UDCA在溶解透X线胆结石方面与餐时服用UDCA的效果相同。每日给药一次对患者来说应该更容易接受。
