[Microbial utilization of mixed substrates].

Decomposition of substrates by heterotrophic microorganisms is accomplished in natural biotopes such as in soil and in waters, on or in macroorganisms but also in laboratory and industrial biotopes. The interest of man in these processes is manifold. Starting with the division of substrates into three groups of simple substrates, complex and mixed substrates with or without solid particles their qualitative and quantitative occurrence in nature and their significance in biotechnology will be discussed. In the decomposition of these substrates their utilization by pure cultures or mixed populations is to be exactly distinguished. Simple growth curves, di- or polyauxy, sequences of decomposition of simple substrates of a mixed substrate, population changes and successions are only some of the phenomena occurring in this process. The pathways of catabolism are subjected to manifold regulations on the three levels of stoichiometric regulation, the regulation of enzyme activity and the regulation of enzyme synthesis. In natural biotopes there is hardly a constant substrate supply over a longer period. That's why certain mechanisms of regulation are permanently acting. Thus the "normal" physiological state for microorganisms is characterized by permanent transition situations--called "transients". These reactions are also applied to many biotechnological processes.