Oxidation of two hydroxylated ochratoxin A metabolites by alcohol dehydrogenase.
作者信息
Syvertsen C, Størmer F C
出版信息
Appl Environ Microbiol. 1983 May;45(5):1701-3. doi: 10.1128/aem.45.5.1701-1703.1983.
Abstract
(4R)-4-hydroxyochratoxin A, (4S)-4-hydroxyochratoxin A, and 10-hydroxyochratoxin A, all formed from ochratoxin A, were incubated with alcohol dehydrogenase in the presence of NAD. Only (4R)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A acted as substrates for the enzyme. K(m) and turnover number for 10-hydroxyochratoxin A were 110 muM and 0.1 s(-1), respectively.
摘要
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Oxidation of two hydroxylated ochratoxin A metabolites by alcohol dehydrogenase.
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本文引用的文献
1
Formation of (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species.不同物种肝脏微粒体将赭曲霉毒素A转化为(4R)-和(4S)-4-羟基赭曲霉毒素A的过程。
Appl Environ Microbiol. 1981 Dec;42(6):1051-6. doi: 10.1128/aem.42.6.1051-1056.1981.
2
Metabolism of ochratoxin A by rats.大鼠对赭曲霉毒素A的代谢
Appl Environ Microbiol. 1982 Oct;44(4):785-9. doi: 10.1128/aem.44.4.785-789.1982.
3
Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes.兔肝微粒体将赭曲霉毒素A转化为(4R)-和(4S)-4-羟基赭曲霉毒素A以及10-羟基赭曲霉毒素A。
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4
DDT metabolism: oxidation of the metabolite 2,2-bis(p-chlorophenyl)ethanol by alcohol dehydrogenase.滴滴涕代谢：酒精脱氢酶对代谢物2,2-双（对氯苯基）乙醇的氧化作用。
Science. 1970 May 1;168(3931):582. doi: 10.1126/science.168.3931.582.
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[Oxidation of allylic alcohols related to vitamin A by horse liver alcohol dehydrogenase].[马肝醇脱氢酶对与维生素A相关的烯丙醇的氧化作用]
C R Acad Hebd Seances Acad Sci D. 1971 Jun 21;272(25):3210-3.
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