新型口咽消毒剂替贝宗的致突变性研究。
Mutagenicity studies on tibezonium, a new oropharyngeal disinfectant.
作者信息
Veronese M, Barzaghi D, Bertoncini A
出版信息
Arzneimittelforschung. 1983;33(3):369-72.
N,N-Diethyl-N-methyl-[2-[[4-(4-phenylthio) phenyl]-3H-1,5-benzodiazepin-2-yl]thio]-ethanaminium iodide) (tibezonium iodide; CAS-54663-47-7), a new oropharyngeal disinfectant, was tested, using the Ames procedure with and without metabolic activation, on five strains of Salmonella typhimurium and using the host mediated assay with Schizosaccharomyces pombe as microorganism test. In both tests the drug did not show any mutagenic activity when compared with mutagenic standards.
N,N - 二乙基 - N - 甲基 - [2 - [[4 - (4 - 苯硫基)苯基] - 3H - 1,5 - 苯并二氮杂䓬 - 2 - 基]硫代]乙铵碘化物（替贝碘铵；CAS - 54663 - 47 - 7），一种新型口咽消毒剂，采用艾姆斯试验，在有和无代谢激活的情况下，对五株鼠伤寒沙门氏菌进行了测试，并采用以粟酒裂殖酵母作为微生物测试的宿主介导试验。在这两种试验中，与诱变标准相比，该药物均未显示出任何诱变活性。
Zotero 插件