Morley C A, Cavalcanti C, Perrins E J, Sutton R
Br J Clin Pharmacol. 1983 Jun;15(6):715-7. doi: 10.1111/j.1365-2125.1983.tb01555.x.
Atenolol 100 mg once daily and metoprolol SA 200 mg once daily were compared in 20 patients with mild to moderate hypertension, in a randomised, double-blind cross-over trial. Blood pressure and heart rate were compared at rest and during maximal exercise on a bicycle ergometer at 2 and 24 h post-dose. Blood pressure control was similar with both drugs, except at 2 h when systolic blood pressure was significantly lower with atenolol. Blood pressure and heart rate were less well controlled at 24 h than at 2 h with both drugs, but the majority of patients were still considered adequately controlled at 24 h. Atenolol and metoprolol SA can be considered equally effective in the treatment of mild to moderate hypertension and can be recommended as a once daily regime.
在一项随机、双盲交叉试验中，对20例轻至中度高血压患者比较了每日一次服用100毫克阿替洛尔和每日一次服用200毫克美托洛尔缓释片的效果。在给药后2小时和24小时，比较了静息时以及在自行车测力计上进行最大运动时的血压和心率。两种药物的血压控制情况相似，但在2小时时，阿替洛尔组的收缩压显著更低。两种药物在24小时时的血压和心率控制均不如2小时时，但大多数患者在24小时时仍被认为得到了充分控制。阿替洛尔和美托洛尔缓释片在治疗轻至中度高血压方面可被视为同样有效，并可推荐作为每日一次的用药方案。
