高血压患者每日服用一次与两次阿替洛尔的比较。
A comparison of once and twice daily atenolol in hypertension.
作者信息
Castleden C M, Dathan J R, George C F
出版信息
Postgrad Med J. 1977 Nov;53(625):679-82. doi: 10.1136/pgmj.53.625.679.
Abstract
The hypertensive action of atenolol has been studied in a randomized double-blind crossover comparison. Twelve patients showed a highly significant reduction in average supine systolic and diastolic blood pressures from pre-treatment values of 196.3/115.9 to 159.1/89.2 mmHg (26.1/15.4 kPa to 22.2/11.9 kPa) after 2 weeks on once daily atenolol. No dose-related reduction in blood pressure was seen and the single 100 mg daily dose was as effective as 100 mg twice daily or 50 mg twice daily. Blood pressures recorded after 2 weeks' atenolol were lower than those obtained at 7 days irrespective of dose.
摘要
在一项随机双盲交叉对照研究中，对阿替洛尔的高血压治疗作用进行了研究。12名患者在每日一次服用阿替洛尔2周后，平均仰卧位收缩压和舒张压从治疗前的196.3/115.9 mmHg（26.1/15.4 kPa）显著降至159.1/89.2 mmHg（22.2/11.9 kPa）。未观察到与剂量相关的血压降低，每日单次100 mg剂量与每日两次100 mg或每日两次50 mg剂量的效果相同。无论剂量如何，服用阿替洛尔2周后的血压均低于7天时测得的血压。
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