Spik G, Montreuil J
Bull Eur Physiopathol Respir. 1983 Mar-Apr;19(2):123-30.
Lactotransferrin is involved in the antibacterial defence of the host by virtue of its reversible iron-binding capacity. On the one hand, it participates in different molecular mechanisms displayed by immunocompetent cells which are known to synthesize or recognize the lactotransferrin. For instance, 1) during inflammation, apolactotransferrin released by the neutrophils captures the iron from serotransferrin which is accumulated by the macrophages, by means of their lactotransferrin membrane receptors; 2) lactotransferrin is an important component in the microbicidal activity of neutrophils by regulating the hydroxyl radical production; 3) lactotransferrin acts as a regulator of myelopoiesis by modulating activity of the colony stimulating factors; 4) lactotransferrin could be involved in the control mechanism of lymphoid cell migration. On the other hand, lactotransferrin participates to the non-specific local secretory immunity by being involved in antibacterial mechanisms together with secretory immunoglobulins sIgA and lysozyme. The different aspects of the participation of the lactotransferrin in the cellular and secretory mechanisms of antibacterial defence of the host show that the lactotransferrin plays a predominant role in the local immunity of any mucosa.
乳铁蛋白凭借其可逆的铁结合能力参与宿主的抗菌防御。一方面，它参与免疫活性细胞所展现的不同分子机制，这些免疫活性细胞已知会合成或识别乳铁蛋白。例如，1）在炎症期间，中性粒细胞释放的脱铁乳铁蛋白通过巨噬细胞的乳铁蛋白膜受体，从巨噬细胞积累的血清转铁蛋白中捕获铁；2）乳铁蛋白通过调节羟自由基的产生，是中性粒细胞杀菌活性的重要组成部分；3）乳铁蛋白通过调节集落刺激因子的活性，作为骨髓生成的调节剂；4）乳铁蛋白可能参与淋巴细胞迁移的控制机制。另一方面，乳铁蛋白通过与分泌型免疫球蛋白sIgA和溶菌酶一起参与抗菌机制，参与非特异性局部分泌免疫。乳铁蛋白参与宿主抗菌防御的细胞和分泌机制的不同方面表明，乳铁蛋白在任何黏膜的局部免疫中都起着主要作用。
