Iwata T, Incefy G S, Good R A, Cunningham-Rundles S, Dardenne M, Kapoor N, Kirkpatrick D, O'Reilly R J
Clin Exp Immunol. 1983 Jul;53(1):1-9.
Twenty-three patients with severe combined immunodeficiency disease were studied for circulating thymic hormone levels (facteur thymique serique, FTS), 21 prior to treatment by transplantation of bone marrow, thymus or fetal liver. Thirteen showed undetectable FTS activity. Only two had normal levels of this hormone. In serial determinations of FTS activity prior to and after transplantation, patients given bone marrow transplants developed sustained increments of serum FTS activity early in the course of their immunological reconstitution. However, patients given transplants of fetal liver alone or fetal liver plus thymus from fetuses of less than 12 weeks gestation generally did not show an increment of FTS activity during the period of observation. Transplantation of irradiated thymus derived from fetuses of more than 14 weeks gestation produced sustained increases of thymic hormone activity. These observations suggest that a cell of haematopoietic origin provides a stimulus necessary for differentiation or maturation of thymic secretory activity and that this cell(s) is present in post-natal marrow, but is either undeveloped or immature in the early fetal liver or fails to migrate to the thymus of an allogeneic host.
对23例重症联合免疫缺陷病患者的循环胸腺激素水平（血清胸腺因子，FTS）进行了研究，其中21例在接受骨髓、胸腺或胎儿肝脏移植治疗前进行了检测。13例患者的FTS活性检测不到。只有2例该激素水平正常。在移植前后对FTS活性进行的系列测定中，接受骨髓移植的患者在免疫重建过程早期血清FTS活性持续增加。然而，仅接受胎儿肝脏移植或接受妊娠不足12周胎儿的胎儿肝脏加胸腺移植的患者，在观察期内一般未显示FTS活性增加。移植妊娠14周以上胎儿的经照射胸腺可使胸腺激素活性持续增加。这些观察结果表明，造血来源的细胞为胸腺分泌活性的分化或成熟提供了必要的刺激，并且这种细胞存在于出生后的骨髓中，但在早期胎儿肝脏中未发育或不成熟，或者未能迁移到同种异体宿主的胸腺中。
