Mizuno S, Cho N
J Int Med Res. 1983;11(3):179-85. doi: 10.1177/030006058301100309.
A double-blind study was conducted comparing a 3-day (200 mg once a day for 3 consecutive days) treatment with a 6-day (100 mg once a day for 6 consecutive days) treatment of clotrimazole in patients with vaginal mycoses. Two days after therapy, fungal eradication was achieved in 87.7% of the patients who received 3-day therapy and 89.1% of patients who received 6-day therapy. With regard to the clinical assessment, 2 days after therapy the symptoms had disappeared in 54.4%, improvement in 42.1%, were unchanged in 1.8%, and aggravated in 1.8% of the 3-day therapy group. The corresponding values in the 6-day group were 63.6%, 34.5%, 1.8% and 0%. Reappearance of fungi was found 2 weeks after therapy in 15.6% of the 3-day treatment group and 8.7% of the 6-day treatment group. No adverse reactions were seen in either group which necessitated the discontinuation of therapy. There were no statistical differences between any of the above results and it is therefore concluded that 3-day clotrimazole therapy is an effective treatment for primary vaginal mycosis.
进行了一项双盲研究，比较了克霉唑对阴道霉菌病患者进行3天治疗（连续3天每天一次200毫克）与6天治疗（连续6天每天一次100毫克）的效果。治疗两天后，接受3天治疗的患者中87.7%实现了真菌根除，接受6天治疗的患者中这一比例为89.1%。关于临床评估，治疗两天后，3天治疗组中症状消失的占54.4%，症状改善的占42.1%，无变化的占1.8%，症状加重的占1.8%。6天治疗组的相应数值分别为63.6%、34.5%、1.8%和0%。治疗两周后，3天治疗组中有15.6%的患者真菌复发，6天治疗组中有8.7%的患者真菌复发。两组均未出现需要停药的不良反应。上述任何结果之间均无统计学差异，因此得出结论，3天克霉唑治疗是原发性阴道霉菌病的有效治疗方法。
