Lebherz T B, Ford L C, Kleinkopf V
Clin Ther. 1981;3(5):344-8.
Patients with mycologically proven symptomatic fungal infections of the vagina were treated ina double-blind trial with either one 100-mg clotrimazole vaginal tablet daily for seven days (group I) or two tablets daily for three days (group II). Patients were evaluated at one and four weeks after therapy. The investigator's evaluation of treatment efficacy showed 85% (22/26) success in group II compared with 75% (21/28) in group I (P = 0.46). Both groups had improvement itching, discharge, and vaginal and vulval irritation. No significant (P less than 0.10) differences were seen between groups after therapy. Only three side effects were seen. It is concluded that a three-day course of two clotrimazole vaginal tablet daily is as effective and safe as the previously recommended one tablet daily for seven days, and the shorter therapy is likely to improve patient compliance.
患有经真菌学证实的有症状阴道真菌感染的患者，在一项双盲试验中接受治疗，一组为每日服用1片100毫克克霉唑阴道片，共7天（第一组），另一组为每日服用2片，共3天（第二组）。在治疗后1周和4周对患者进行评估。研究者对治疗效果的评估显示，第二组的成功率为85%（22/26），而第一组为75%（21/28）（P = 0.46）。两组患者的瘙痒、分泌物以及阴道和外阴刺激症状均有改善。治疗后两组之间未见显著（P＜0.10）差异。仅观察到3例副作用。得出的结论是，每日服用2片克霉唑阴道片、疗程为3天的治疗方法与先前推荐的每日1片、疗程为7天的方法一样有效和安全，且较短疗程可能会提高患者的依从性。
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