Hedbäck B, Parment K
J Int Med Res. 1983;11(3):190-3. doi: 10.1177/030006058301100311.
The antihypertensive effect of verapamil 200 mg b.i.d. was compared with that of verapamil 120 mg t.i.d. in a double-blind crossover study of eight out-patients with essential hypertension. The mean supine blood pressure measured before the morning dose was 150/87 mm Hg in patients treated with verapamil 200 mg b.i.d. and 151/87 mm Hg in those treated with verapamil 120 mg t.i.d. The recently reported prolonged half-life and accumulation of verapamil during steady-state conditions explains the lasting antihypertensive effect with the twice-daily dose regimen. Such a twice daily dose regimen is presumed to be more convenient to the patients and thus improve their compliance.
在一项针对8名原发性高血压门诊患者的双盲交叉研究中，对比了维拉帕米每日两次、每次200毫克的降压效果与维拉帕米每日三次、每次120毫克的降压效果。接受每日两次、每次200毫克维拉帕米治疗的患者，早晨服药前测得的平均仰卧血压为150/87毫米汞柱；接受每日三次、每次120毫克维拉帕米治疗的患者，早晨服药前测得的平均仰卧血压为151/87毫米汞柱。最近报道的维拉帕米在稳态条件下延长的半衰期和蓄积现象，解释了每日两次给药方案具有持久降压效果的原因。据推测，这种每日两次的给药方案对患者来说更方便，从而提高了他们的依从性。
