Atti G, Capra L, De Sanctis V, Vullo C, Bagni B
Helv Paediatr Acta. 1983 May;38(2):123-32.
In order to investigate the pancreatic function in patients with thalassaemia major, plasma glucose and immunoreactive C-peptide levels were determined in 9 diabetic thalassaemic patients and in 7 controls after arginine infusion. Mean basal and peak values and C-peptide areas in thalassaemic patients did not differ significantly from those of the controls. However, in the thalassaemic group there was a greater variation in values, since pancreatic beta-cell function was found either normal, reduced or increased. These findings could suggest that different factors may lead to diabetes which complicates thalassaemia, i.e. insulin-resistance, probably due to liver damage subsequent to iron deposition and infectious hepatitis, and insulinopenia, probably due to beta-cell lesion following iron storage in the pancreas.
为了研究重型地中海贫血患者的胰腺功能，对9例糖尿病地中海贫血患者和7例对照者在输注精氨酸后测定了血浆葡萄糖和免疫反应性C肽水平。地中海贫血患者的平均基础值、峰值及C肽面积与对照组相比无显著差异。然而，在地中海贫血组中，数值变化更大，因为发现胰腺β细胞功能正常、降低或增强。这些发现提示，不同因素可能导致地中海贫血并发糖尿病，即胰岛素抵抗，可能是由于铁沉积和传染性肝炎导致的肝损伤，以及胰岛素缺乏，可能是由于胰腺中铁储存后β细胞病变。
