Brushart T M, Tarlov E C, Mesulam M M
J Hand Surg Am. 1983 May;8(3):248-53. doi: 10.1016/s0363-5023(83)80152-x.
We experimentally analyzed the specificity of muscle reinnervation after suture and regeneration of rat sciatic nerve. We used a horseradish peroxidase (HRP) technique of axon tracing to compare the number and location of motoneurons that innervate muscle via the peroneal nerve after epineurial and individual fascicular suture of the parent sciatic nerve. These motoneurons are significantly reduced in number from control levels and are often in spinal cord locations that indicate previous innervation of antagonistic muscle via the tibial nerve. This inappropriate reinnervation of peroneal muscle by tibial motoneurons is minimized by individual fascicular suture without compromise of overall reinnervation. Our findings thus support the hypothesis that individual fascicular suture may avoid distortion of the central connections of peripheral units.
我们通过实验分析了大鼠坐骨神经缝合与再生后肌肉再支配的特异性。我们采用辣根过氧化物酶（HRP）轴突追踪技术，比较了在坐骨神经主干进行神经外膜缝合和单束缝合后，经腓总神经支配肌肉的运动神经元的数量和位置。这些运动神经元的数量相较于对照水平显著减少，并且其在脊髓中的位置往往表明先前通过胫神经对拮抗肌的支配。通过单束缝合，胫神经运动神经元对腓骨肌的这种不适当再支配得以最小化，同时又不影响整体的再支配。因此，我们的研究结果支持了这样一种假说，即单束缝合可能避免外周单位中枢连接的扭曲。
