Gotfredsen A, Christiansen C, Transbøl I
Maturitas. 1983 Jun;5(1):9-15. doi: 10.1016/0378-5122(83)90016-6.
Uric acid metabolism was studied in groups of early post-menopausal women before and during long-term administration of natural oestrogen/gestagen (n = 21), bendroflumethiazide (n = 19) or placebo (n = 34). Serum uric acid rose definitely, by 13.0% during thiazide, and decreased slightly, by 4.9%, during hormone treatment. The latter deviation did not differ significantly from that of -2.9% seen in the placebo group. The urinary excretion rates of uric acid observed during thiazide and hormone treatment did not differ significantly from that of the placebo group. It is concluded, that within the present design of study, which readily permits detection of the well-known hyperuricaemic action of thiazide, oestrogen/gestagen hardly affects uric acid metabolism.
对绝经后早期女性群体进行了研究，观察她们在长期服用天然雌激素/孕激素（n = 21）、苄氟噻嗪（n = 19）或安慰剂（n = 34）之前及期间的尿酸代谢情况。血清尿酸在服用噻嗪类药物期间明显升高，升幅为13.0%，而在激素治疗期间略有下降，降幅为4.9%。后一偏差与安慰剂组观察到的-2.9%没有显著差异。在噻嗪类药物和激素治疗期间观察到的尿酸尿排泄率与安慰剂组没有显著差异。得出的结论是，在本研究设计中，该设计易于检测出噻嗪类药物众所周知的高尿酸血症作用，雌激素/孕激素几乎不影响尿酸代谢。
