Staland B
Maturitas. 1981 Aug;3(2):145-56. doi: 10.1016/0378-5122(81)90006-2.
Treatment of menopausal symptoms with a combination of natural oestrogens (17beta-oestradiol and oestriol) and a gestagen (norethisterone acetate), given continuously without interruption, has been found to have a good effect on menopausal symptoms, at the same time as the endometrium is maintained or brought to an atrophic state. This method seems to be a new approach to oestrogenic therapy, and in spite of the inconvenience of rather frequent--though as a rule very slight--bleeding during the first months of treatment, it should be of value. After 3-4 mth of treatment bleeding practically never occurs and the endometrium almost invariably becomes completely atrophic. It would seem that this might imply a lowered risk of development of endometrial cancer. A series of 265 patients treated in accordance with this principle for up to more and than 4 yr is presented.
采用天然雌激素（17β - 雌二醇和雌三醇）与孕激素（醋酸炔诺酮）联合使用且不间断持续给药的方法治疗更年期症状，已发现其对更年期症状有良好效果，同时能使子宫内膜维持或进入萎缩状态。这种方法似乎是雌激素治疗的一种新途径，尽管在治疗的最初几个月会出现相当频繁（通常非常轻微）的出血这种不便情况，但仍应具有价值。治疗3 - 4个月后几乎不再出血，子宫内膜几乎总是完全萎缩。这似乎意味着子宫内膜癌发生风险降低。本文展示了按照这一原则治疗长达4年多的265例患者的系列情况。
