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[钙代谢的激素调节及Ca2+对激素分泌的调节]

[Hormonal regulation of calcium metabolism and regulation of hormone secretion by Ca2+].

作者信息

Schreier K

出版信息

Monatsschr Kinderheilkd. 1983 May;131(5):244-50.

PMID:6348516
Abstract

In a short review the spectacular discoveries in the field of the Ca-homeostasis are delineated. To begin with, the structure and function of parathyroid hormone and of calcitonin are described, whereas the influence of the tocolytica, the catecholamines and glucagon are only touched. Other short chapters deal with the energetic processes during Ca2+ efflux and influx as well as the intracellulare Ca2+-homeostasis. In greater detail the metabolic changes of vitamin D3 and of 1,25 (OH2) D3 in the human organism are described and the action of the latter-hormone in the entire Ca-metabolism is reviewed. With the model of insulin the decisive importance of ca2+ for release of different hormones is demonstrated.

摘要

在一篇简短的综述中,描述了钙稳态领域的惊人发现。首先,阐述了甲状旁腺激素和降钙素的结构与功能,而仅提及了宫缩抑制剂、儿茶酚胺和胰高血糖素的影响。其他简短章节讨论了钙离子外流和内流过程中的能量过程以及细胞内钙稳态。更详细地描述了人体中维生素D3和1,25(OH)2D3的代谢变化,并综述了后一种激素在整个钙代谢中的作用。以胰岛素模型为例,证明了钙离子对不同激素释放的决定性重要性。

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